Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C
โ Scribed by Nagaoki, Yuko; Imamura, Michio; Kawakami, Yoshiiku; Kan, Hiromi; Fujino, Hatsue; Fukuhara, Takayuki; Kobayashi, Tomoki; Ono, Atsushi; Nakahara, Takashi; Naeshiro, Noriaki; Urabe, Ayako; Yokoyama, Satoe; Miyaki, Daisuke; Murakami, Eisuke; Kawaoka, Tomokazu; Tsuge, Masataka; Hiramatsu, Akira; Aikata, Hiroshi; Takahashi, Shoichi; Hayes, C. Nelson; Ochi, Hidenori; Chayama, Kazuaki
- Book ID
- 121654109
- Publisher
- John Wiley and Sons
- Year
- 2014
- Tongue
- English
- Weight
- 486 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1386-6346
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## Abstract Hepatitis C Virus (HCV) is classified into six genotypes. Genotype 4 is now spreading in Europe, especially among drug users, who are often infected with both HCV and the human immunodeficiency virus (HIV). Previous studies have shown that HCVโ4 responds poorly to interferon. Pegylated
Single nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) region are the strongest baseline predictors of a sustained virologic response (SVR) to peg-interferon (PegIFN) and ribavirin (Rbv) in patients with hepatitis C virus (HCV) genotype 1 infection. Whether this holds true for HCV-4