Interferon-gamma gene expression during acute graft-versus-host disease: relationship to MHC induction and tissue injury
✍ Scribed by Parfrey, Nollaig A.; El-Sheikh, Amr; Monckton, Elizabeth A.; Cockfield, Sandra M.; Halloran, Philip F.; Linetsky, Elina
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 324 KB
- Volume
- 189
- Category
- Article
- ISSN
- 0022-3417
No coin nor oath required. For personal study only.
✦ Synopsis
The pathogenetic role of interferon-(IFN-) in acute graft-versus-host disease (GVHD) was examined in a murine model. IFN-gene expression was evaluated by northern blotting and mRNA in situ hybridization. The temporal and tissue specific patterns of IFN-gene expression were related to the patterns of major histocompatibility complex (MHC) antigen induction and of tissue injury. Markedly increased levels of IFN-transcripts were seen in the spleen during the early lymphoproliferative phase and coincided with widespread MHC induction in non-lymphoid tissues. Increased IFN-transcripts were also found in the non-lymphoid target tissues during the phase of subsequent tissue injury. These findings support a role for IFN-in leading to widespread MHC induction during acute GVHD and suggest that IFN-may also contribute to target tissue injury during acute GVHD.