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Interferon alfa-2c in chronic myelogenous leukemia (CML): Hematologic, cytogenetic and molecular-genetic response of patients with chronic phase CML previously resistant to therapy with interferon gamma

โœ Scribed by Herrmann, F. ;Jonas, D. ;Helfrich, S. G. ;Lindemann, A. ;Schleiermacher, E. ;Mertelsmann, R.


Publisher
Springer-Verlag
Year
1990
Weight
849 KB
Volume
61
Category
Article
ISSN
1432-0584

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## BACKGROUND. T-cell lymphoid blastic phase (BP) transformation is rare in chronic myelogenous leukemia (CML). 2-amino-9-โค-D-arabinosyl-6-methoxy-9H-guanine (GW506U78), a prodrug of arabinosylguanine (ara-G), is effective in T-cell leukemias. ## METHODS. The authors present a case of a 48-year