To elucidate the risk factors for liver carcinogenesis and to examine the incidence of hepatocellular carcinoma (HCC) after interferon therapy, 1,022 chronic hepatitis C patients treated with interferon were followed by ultrasonography for 13 to 97 months (median 36 months). Sustained response with
Interferon alfa-2a treatment for chronic hepatitis C without cirrhosis and its effects on the incidence of hepatocellular carcinoma
โ Scribed by Katsuhisa Omagari; Nobuhiro Ikuno; Takeo Imanishi; Kenji Hayashida; Ken-ichiro Inoue; Masahiro Senju; Norihiko Mori; Toshiro Tanaka; Koji Nakamuta; Hidetoshi Oda; Atsushi Minamino; Kohei Komatsu; Yasuko Nomura; Shigeru Kohno
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 463 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1341-321X
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BACKGROUND. Interferon (IFN) has been reported to have beneficial long term effects that reduce the occurrence of hepatocellular carcinoma (HCC), even in patients who do not have complete responses to IFN. The authors evaluated the effect of retreatment with IFN-โฃ on the long term prognoses of those
Combination treatment with pegylated-interferon-alpha (PEG IFN-โฃ) and ribavirin, the current recommended therapy for chronic hepatitis C virus (HCV) infection, results in a sustained virological response (SVR) in only about half of patients. Because genes involved in the interferon-alpha pathway may