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Interferon: a cytotoxic T lymphocyte differentiation signal

✍ Scribed by Likuang Chen; Bcatrice Tourvieille; Gordon F. Burns; Fritz H. Bach; Danièle Mathieu-Mahul; Marilyne Sasportes; Armand Bensussan

Book ID
102160812
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
407 KB
Volume
16
Category
Article
ISSN
0014-2980

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✦ Synopsis

Interferon: a cytotoxic T lymphocyte differentiation signal

Human T cell clones which were able to proliferate in response to specific stimuli but could not kill even in the presence of lectins were found to acquire the specific lytic function when interferon alpha or gamma was added on day 1 of the 7-day restimulation culture. These results demonstrate that interferon may act as a cytotoxic T lymphocyte differentiation signal. This signal can be blocked by the monoclonal antibody LeoAl which recognizes a 70-kDa cell surface structure, involved in cytotoxic T lymphocyte differentiation.

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