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Interference with nitric oxide production and action potentiates the antiseizure efficacy of flurazepam

✍ Scribed by Stephen I. Deutsch; Richard B. Rosse; Cassandra Morn; Lee Koetzner; John Mastropaolo

Book ID
113225942
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
510 KB
Volume
51
Category
Article
ISSN
0091-3057

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## Abstract Both transforming growth factor‐β1 (TGF‐β1) and nitric oxide synthase‐2 (NOS‐2) are upregulated under various neuropathological states. Evidence suggests that TGF‐β1 can either attenuate or augment NOS‐2 expression, with the prevailing effect dependent on the experimental paradigm emplo