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Interference of Nonsense Mutations with Eukaryotic Messenger RNA Stability

✍ Scribed by Regine Losson and Francois Lacroute


Book ID
123656097
Publisher
National Academy of Sciences
Year
1979
Tongue
English
Weight
693 KB
Volume
76
Category
Article
ISSN
0027-8424

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Germline mutations that give rise to premature termination codons in mRNAs have frequently been associated with aberrant processing of the nascent transcripts. This can take the form either of nonsense-mediated mRNA decay or of aberrant splicing of the pre-mRNA. In a family affected by hereditary no