Interfacial properties of phenothiazine derivatives

✍ Scribed by George Zograft; David E. Auslander; Peter L. Lytell

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 158 KB
• Volume: 53
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600530528

✦ Synopsis

Recent publications have indicated that chlorpromazine and other phenothiazine derivatives accumulate at biological membranes (1-3), and that these membranes might be the site of pharmacological activity. This view is strengthened by recent work, which has demonstrated the active role of mitochondria1 phospholipid membranes during oxidative phosphorylation (4), and by the fact that chlorpromazine has been shown to interfere with electron transport by uncoupling oxidative phosphorylation (5, 6).