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Interconversion of replication and recombination structures: Implications for terminal repeats and concatemers

✍ Scribed by A. Richard Morgan; Alberto Severini

Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 470 KB
Volume: 144
Category: Article
ISSN: 0022-5193
DOI: 10.1016/s0022-5193(05)80318-2

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✦ Synopsis

Replication and recombination structures can be interconverted by branch-migration. Using this simple concept a novel mechanism is proposed for generating concatemers through an initial single-strand DNA invasion into a duplex. Only DNAs with terminal repeats can form concatemers, and Herpes Simplex Virus DNA replication is considered in detail. The model is more parsimonious than other models such as Watson's for concatemer formation.

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