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Interchangeable PEG-Supported Synthesis of Peptide-Oligonucleotide Chimeras

✍ Scribed by Ilaria Adamo; Maurizio Ballico; Pietro Campaner; Sara Drioli; Gian Maria Bonora

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
171 KB
Volume
2004
Category
Article
ISSN
1434-193X

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## Abstract Peptide nucleic acids (PNA) and PNA–DNA chimeras carrying thiol groups were used for surface functionalization of Au nanoparticles. Conjugation of PNA to citrate‐stabilized Au nanoparticles destabilized the nanoparticles causing them to precipitate. Addition of a tail of glutamic acid t