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Interchain Cross-Linking of DNA Mediated by the Principal Adduct of Acrolein

✍ Scribed by Kozekov, Ivan D.; Nechev, Lubomir V.; Sanchez, Ana; Harris, Constance M.; Lloyd, R. Stephen; Harris, Thomas M.

Book ID
126287159
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
49 KB
Volume
14
Category
Article
ISSN
0893-228X

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Incubation of homogenates of rat nasal mucosa with acrolein resulted in the apparent formation of DNAprotein cross-links. However, inhalation exposure of male Fischer-344 rats to acrolein (2.0 ppm, 6 h) did not cause detectable DNA-protein cross-linking in the nasal respiratory mucosa. Simultaneous