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Intercellular gap junctional communication is required for an optimal metabolic response of the functional units of liver

✍ Scribed by J C Saez

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 129 KB
Volume: 25
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.510250348

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✦ Synopsis

INTERCELLULAR GAP JUNCTIONAL COMMUNICATION

function in fact depends on proper function of GJs, and, until now, there has been no such evidence in liver. Indeed, it was

IS REQUIRED FOR AN OPTIMAL METABOLIC RESPONSE OF THE FUNCTIONAL UNITS OF LIVER

HEPATOLOGY March 1997 JC. Organization of intercellular Ca 2/ waves in rat liver. Am J Physiol throughout the hepatic lobule but Cx26 is predominantly in 1995;269:G167-G171. periportal hepatocytes. In the Cx32-deficient mouse, Cx26 8. Robb-Gaspers LD, Thomas AP. Coordination of Ca 2/ signaling by intercellu- was drastically down-regulated, probably because of a destalar propagation of Ca 2/ waves in the intact liver.

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Molecular mechanisms of TPA-mediated inh

Molecular mechanisms of TPA-mediated inhibition of Gap-junctional intercellular communication: Evidence for action on the assembly or function but not the expression of connexin 43 in rat liver epithelial cells

✍ Makoto Asamoto; Masahito Oyamada; Abdelhakim El Aoumari; Daniel Gros; Hiroshi Ya 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 563 KB

We found that a rat liver epithelial cell line (IAR 20) expresses connexin 43, the major cardiac gap-junction protein, but not connexin 26 or connexin 32, major liver gap-junction proteins. The effects of TPA on connexin 43 expression in IAR 20 were investigated using northern blot analysis, western