The role of adenosine receptor-mediated signaling was examined in the alcohol withdrawal syndrome. CD-1 mice received a liquid diet containing ethanol (6.7%, v/v) or a control liquid diet that were abruptly discontinued after 14 days of treatment. Mice consuming ethanol showed a progressive increase
Interactive role of adenosine and dopamine in the opiate withdrawal syndrome
β Scribed by Luigi Stella; Vito de Novellis; Maria Redenta Vitelli; Annalisa Capuano; Filomena Mazzeo; Liberato Berrino; Francesco Rossi; Amelia Filippelli
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 411 KB
- Volume
- 368
- Category
- Article
- ISSN
- 0028-1298
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Methylxanthines produce a quasi-morphine withdrawal syndrome (QMWS) in opiate naive rats. Additionally, methylxanthine-induced suppression of conditioned behavior in rats is reversed by the alpha2 adrenergic agonist clonidine which also attenuates true opiate withdrawal and the QMWS. Therefore, the
The effects of the cholinergic agents UM-1046 (3-cyclopropyl-methyl-1,2,3,4,5,6-hexahydro-8-hydroxy-6-methyl-3-benz azo cine hydrochloride) and physostigmine in normal rhesus monkeys were compared to naloxone-precipitated withdrawal in morphine-dependent subjects. The two cholinergic drugs produced