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Interactions of the enantiomers of 3-O-methyldobutamine with α- and β-adrenoceptors in vitro

✍ Scribed by Robert R. Ruffolo; Karen Messick; J. S. Horng


Book ID
112345153
Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
977 KB
Volume
329
Category
Article
ISSN
0028-1298

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The stereoselectivity of carvedilol, a novel P-adrenoceptor antagonist and vasodilator with one asymmetric carbon atom, was examined a t al-and p,-adrenoceptors in vitro and in vivo. (-)-(S)-Carvedilol is a potent, competitive antagonist of the PI -adrenoceptor-mediated positive chronotropic respons