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Interactions of nucleic acids with distamycins. The drug monomeric chromophore

โœ Scribed by A. Forni; I. Moretti; G. Torre; G. Marconi; B. Samori

Publisher
Wiley (John Wiley & Sons)
Year
1989
Tongue
English
Weight
710 KB
Volume
28
Category
Article
ISSN
0006-3525

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โœฆ Synopsis

A study of the monomeric chromophore of the oligopeptides netropsin (1), distamycin III (2), and distamycin V (3) by polarization spectroscopy techniques and molecular orbital calculations is reported. Linear dichroism spectra of the monomeric model compounds 1-methyl-2(ethylcarbamoyl)-4-acetamido-pyrrole (4) and 1-methyl-2(ethylcarbamoyl)-pyrrole (5) dissolved and oriented in lyotropic and thermotropic liquid crystals provide, together with the magnetic CD spectra, experimental checks of the theoretical calculations. The polarization directions of the investigated transition obtained by these means in this study allow us to build up in the following paper the exciton states of (1)-(3) and these provide a stereochemical interpretation of the flow linear dichroism spectra of the complexes of DNA with (2) and (3).

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