✦ LIBER ✦

Interactions of Mitochondrial ATP Synthesis and the Creatine Kinase Equilibrium in Skeletal Muscle

✍ Scribed by G.J Kemp

Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 384 KB
Volume: 170
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.1994.1184

No coin nor oath required. For personal study only.

✦ Synopsis

In skeletal muscle, creatine kinase imposes constraints on the concentrations of phosphocreatine, creatine, ATP and ADP, which complicate our understanding of the regulation of mitochondrial ATP synthesis, because correlations between oxidation rate ((Q)) and metabolite concentrations cannot prove causal relations. Two kinds of theory of mitochondrial control in vivo have evolved, based on (i) the hyperbolic relationship between (Q) and cytosolic [ADP] and (ii) linear correlations between (Q) and, for example, free energy of ATP hydrolysis. This paper examines some relationships between these theories in order to show (i) to what extent they may be regarded as different expressions of the same metabolic mechanisms, (ii) how they can be understood in terms of general principles of feedback control, and (iii) how they explain relationships between mitochondrial function and resting metabolite concentrations.

📜 SIMILAR VOLUMES

Saturation and inversion transfer studie

Saturation and inversion transfer studies of creatine kinase kinetics in rabbit skeletal muscle in vivo

✍ Paul S. Hsieh; Robert S. Balaban 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 English ⚖ 462 KB

The steady-state kinetics of the creatine kinase reaction in rabbit skeletal muscle in vivo was investigated using inversion and saturation magnetization transfer techniques. Both techniques determined the forward rate of this reaction (creatine phosphate ATP) as approximately 0.3 s-1. This correspo

The creatine kinase equilibrium, free [A

The creatine kinase equilibrium, free [ADP] and myosin ATPase in vascular smooth muscle cross-bridges

✍ Joseph F. Clark; Graham J. Kemp; George K. Radda 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 284 KB

MgADP has a more pronounced effect on the relaxation behaviour in tonic vascular smooth muscle compared to phasic smooth muscle. An apparent dissociation constant of 1.3 mM has been reported for a high affinity binding site of vascular smooth muscle cross-bridges. For this high affinity to have an e

Geographic distribution of xanthine oxid

Geographic distribution of xanthine oxidase, free radical scavengers, creatine kinase, and lactate dehydrogenase enzyme systems in rat heart and skeletal muscle

✍ Apple, Fred S. ;Hyde, John E. ;Ingersoll-Stroubos, Ann Marie ;Theologides, Athan 📂 Article 📅 1991 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 460 KB 👁 1 views

## Abstract The geographic distribution of the following enzyme systems is described in the rat heart (left and right ventricles) and in different skeletal muscles (soleus, plantaris, and red and white gastrocnemius): xanthine oxidase and dehydrogenase, creatine kinase isoenzymes, lactate dehydroge

Muscle biopsy in the evaluation of patie

Muscle biopsy in the evaluation of patients with modestly elevated creatine kinase levels

✍ Zachary Simmons; B. Lee Peterlin; Philip J. Boyer; Javad Towfighi 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 59 KB

Age-associated mitochondrial DNA deletio

Age-associated mitochondrial DNA deletions in mouse skeletal muscle: Comparison of different regions of the mitochondrial genome

✍ Eimon, Peter M. ;Chung, Susan S. ;Lee, Connie M. ;Weindruch, Richard ;Aiken, Jud 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 747 KB

The abundance of mitochondrial DNA (mtDNA) deletions has been shown to increase with age in a number of species and may contribute to the aging process. Estimating the total mtDNA deletion load of an individual is essential in evaluating the potential physiological impact. In this study, we compared

Effects of ischemia on skeletal muscle e

Effects of ischemia on skeletal muscle energy metabolism in mice lacking creatine kinase monitored by in vivo31P nuclear magnetic resonance spectroscopy

✍ H. J. A. in ‘t Zandt; F. Oerlemans; B. Wieringa; A. Heerschap 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 2 views

The aim of this study was to provide in vivo experimental evidence for the proposed biological significance of the creatine kinase (CK)/phosphocreatine (PCr) system in the energy metabolism of skeletal muscle. As a test system we compared hindlimb muscle of knockout mice lacking the cytosolic M-type