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Interactions of KLVFF-PEG Peptide Conjugate with Fibrinogen in Neutral Aqueous Solutions

✍ Scribed by Valeria Castelletto; Gemma E. Newby; Ian W. Hamley

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
275 KB
Volume
8
Category
Article
ISSN
1616-5187

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✦ Synopsis

Abstract

In this work we report on the interaction of KLVFF‐PEG with fibrinogen (Fbg) in neutral aqueous solutions at 20 °C, for particular ratios of KLVFF‐PEG to Fbg concentration, Δ = c~KLVFF‐PEG~/c~Fbg~. Our results show the formation of Fbg/KLVFF‐PEG complexes for Δ > 0, such that there is not an extended network of complexes throughout the solution. In addition, cleaved protein and Fbg dimers are identified in the solution for Δ ≥ 0. There is a dramatic change in the tertiary structure of the Fbg upon KLVFF‐PEG binding, although the KLVFF‐PEG binds to the Fbg without affecting the secondary structure elements of the glycoprotein.

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