Interactions of charatoxins and nereistoxin with the nicotinic acetylcholine receptors of insect cns and Torpedo electric organ
โ Scribed by Shebl M. Sherby; Amira T. Eldefrawi; Jonathan A. David; David B. Sattelle; Prof. Mohyee E. Eldefrawi
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 894 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0739-4462
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Purified Torpedo nobiliana electric organ acetylcholine receptor (AChR) was reconstituted into membranes containing natural phospholipids supplemented with cholesterol (25% w/w). The reconstituted system facilitates the study of the effects of drugs on the regulation of the AChR channel complex unde
## Abstract A new promising galanthamine derivative, 10โ[^3^H]methylgalanthamine iodide, was synthesized for binding studies to nicotinic acetylcholine receptors expressed in Torpedo electric ray electroplaques. Galanthamine was reacted with [^3^H]methyl iodide to yield 10โ[^3^H]methylgalanthamine