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Interactions of amphiphilic drugs withα-,β-, andγ-cyclodextrins

✍ Scribed by N. Takisawa; K. Shirahama; I. Tanaka

Publisher
Springer
Year
1993
Weight
546 KB
Volume
271
Category
Article
ISSN
0340-255X

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Promethazine hydrochloride (PTZ) is an amphiphilic drug derived from the phenothiazine structure that possesses a charged aliphatic chain with a chiral carbon. In the presence of beta-cyclodextrin (beta-CD), this drug undergoes significant changes of its photophysical properties in aqueous solution.