Interactions between α-amino acids and cobalt(II) bovine-carbonic anhydrase

✍ Scribed by I. Bertini; C. Luchinat; A. Scozzafava

• Publisher: Elsevier Science
• Year: 1977
• Weight: 426 KB
• Volume: 7
• Category: Article
• ISSN: 0006-3061
• DOI: 10.1016/s0006-3061(00)80096-4

✦ Synopsis

The results of a study on the interaction between cobalt(II) bovine carbonic anhydrase and the a-amino acids L(s) and D(-Manine. glycine and betaine are reported_ L(+)ahnine and glycine base been found to have larger aftinity for the enzyme than II(-) alanine whereas no sizable affinity is shown by betaine. The electronic spectra indicate that these systems are similar to that containing the acetate ion. Utilizing the inhibition properties of L(+)alanine at various pH an analysis of the species involved in the inhibition reaction is presented.