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Interactions between verapamil and metoprolol in the developing chick embryo heart

✍ Scribed by Toshio Nishikawa; Takeshi Kasajima; Takao Kanai

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
350 KB
Volume
11
Category
Article
ISSN
0260-437X

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✦ Synopsis

Abstract

A calcium blocking agent, verapamil, and a β~1~‐adrenoreceptor blocking agent, metoprolol, were administered alone or in combination to 4‐day‐old chick embryos (Hamburger‐Hamilton developmental stage 24). Embryos co‐administered with verapamil (0.05 nmol) and metoprolol (0.1 or 1.0 nmol), neither of which alone caused significant teratogenicity, showed cardiovascular malformations, including ventricular septal defects associated with or without dextroposition of the aorta (overriding aorta). The alteration of calcium movement into the myocyte and/or the haemodynamic change following impaired calcium transport are suggested to be possible causative factors.

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