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Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid β toxicity in Alzheimer’s disease

✍ Scribed by Gideon M. Shaked; Stephanie Chauv; Kiren Ubhi; Lawrence A. Hansen; Eliezer Masliah


Book ID
111312925
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
795 KB
Volume
276
Category
Article
ISSN
1432-1327

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## Abstract The β‐amyloid protein (Aβ) is derived by proteolytic processing of the amyloid protein precursor (APP). Cleavage of APP by β‐secretase generates a C‐terminal fragment (APP‐CTFβ), which is subsequently cleaved by γ‐secretase to produce Aβ. Our previous studies have shown that the proteas