Interactions between T lymphocytes and endothelial cells in allograft rejection

✍ Scribed by David M Briscoe; Stephen I Alexander; Andrew H Lichtman

• Publisher: Elsevier Science
• Year: 1998
• Tongue: English
• Weight: 727 KB
• Volume: 10
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(98)80218-5

✦ Synopsis

Vascular endothelial cells participate in the process of allograft rejection by promoting both the recruitment and the activation of alloreactive T cells. There have been three major recent advances in the field of interactions between T cells and endothelial cells that are of direct relevance to the process of cell-mediated responses to allografts: first, endothelial cells mediate selective recruitment of CD4 + T cell subsets, including naive and memory T cells and T cell subsets of the Thl and Th2 phenotypes; second, endothelial cells costimulate the production of effector cytokines by helper T cells; and third, endothelial cells regulate T cell apoptosis.