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Interactions between naloxone and chlorpromazine on behavior under schedule control

✍ Scribed by D. E. McMillan

Publisher: Springer
Year: 1971
Tongue: English
Weight: 357 KB
Volume: 19
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00402636

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✦ Synopsis

A multiple fixed-ratio, fixed-interval schedule of food presentation was used to study interactions between naloxone and chlorpromazine in the pigeon. Inactive doses of both drugs could combine to decrease the rate of responding under both schedule components. Inactive doses of naloxone could enhance the rate-decreasing effects of chlorpromazine and inactive doses of ehlorpromazine could enhance the rate-decreasing effects of naloxone. When both drugs decreased the rate, the combined effects of the drugs was greater than the sum of the ratedecreasing effects of the individual drugs. These data suggest that the rate-decreasing effects of naloxone and chtorpromazine are synergistic.

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