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Interactions Between Acyclic and Cyclic Peralkylammonium Compounds and DNA

✍ Scribed by Prof. Dr. Hans-Jörg Schneider; Dipl.-Chem. Thomas Blatter

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
275 KB
Volume
31
Category
Article
ISSN
0044-8249

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✍ Jan Nygren; Nicke Svanvik; Mikael Kubista 📂 Article 📅 1998 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 303 KB

The interaction of the fluorescent dye thiazole orange (TO) with nucleic acids is characterized. It is found that TO binds with highest affinity to double-stranded (ds) DNA [log(K) É 5.5 at 100 mM salt], about 5-10 times weaker to single-stranded polypurines, and further 10-1000 times weaker to sing