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Interactions between 1α,25(OH)2D3 and residues in the ligand-binding pocket of the vitamin D receptor: A correlated fragment molecular orbital study

✍ Scribed by Kenji Yamagishi; Hiroaki Tokiwa; Makoto Makishima; Sachiko Yamada


Book ID
116698487
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
552 KB
Volume
121
Category
Article
ISSN
0960-0760

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## Abstract The Runx2 transcription factor is a key regulator of osteoblast differentiation. In response to 1α,25 dihydroxy vitamin D3, Runx2 may interact with the 1α,25 dihydroxy vitamin D3 receptor (VDR) in the promoter of target genes, producing a synergic activation of their transcription. Prev