Interaction studies of tilomisole, aspirin, and naproxen in acute and chronic inflammation with assessment of gastrointestinal irritancy in the rat

Studies on the mechanism of haloacetonit

Studies on the mechanism of haloacetonitrile-induced gastrointestinal toxicity: Interaction of dibromoacetonitrile with glutathione and glutathione-S-transferase in rats

✍ Ahmed, Ahmed E. ;Hussein, Gamal I. ;Loh, Jiann-Ping ;Abdel-Rahman, Sherif Z. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 672 KB

## Abstract The haloacetonitrile, dibromoacetonitrile (DBAN), is a direct‐acting genotoxic agent that has been detected in drinking water. In a time course study, male Sprague‐Dawley rats were treated with DBAN (75 mg/kg PO), and killed at 0.5, 1, 2, and 4 hr after treatment. In a dose response stu