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Interaction Studies of Cationic Drugs with Anionic Polyelectrolytes I: Sodium Carboxymethylcellulose

✍ Scribed by Kennon, Lloyd ;Higuchi, Takeru

Publisher
Elsevier
Year
1956
Weight
355 KB
Volume
45
Category
Article
ISSN
0095-9553

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✦ Synopsis

A study of the interaction of sodium carboxymethylcellulose with a number of cationic drugs indicated that even prior to the formation of visible reaction products, binding of the drug ions on the dissolved polyelectrolyte occurs. It has been shown that CMC forms complexes in this manner with the cationic drugs uinine, Benadryla, procaine, and Pyribenzaminem With amphetamine and epxedrine only the Donnan effect a pears to be operative. Sodium chloride will to a great extent displace the born8 cations from-the CMC. A method utilizing a dialysis technique and Donnan eqmlibrium concepts has been presented.

HE INCORPORATION of polyelectrolytes in

Tpharmaceutical systems is more prevalent presently than was formerly the case. The significance of their value in considerations of drug insolubilization, appearance, and stability, and also in prolongation of action is appreciated to a greater extent. The latter two facets of polyelectrolyte application are the ones which are apparently receiving the most attention in industrial pharmaceutical research currently.

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