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Interaction Profile of Armodafinil with Medications Metabolized by Cytochrome P450 Enzymes 1A2, 3A4 and 2C19 in Healthy Subjects

✍ Scribed by Dr Mona Darwish, Mary Kirby, Philmore Robertson Jr, Edward T. Hellriegel

Book ID
119926844
Publisher
Springer International Publishing AG
Year
2008
Tongue
English
Weight
169 KB
Volume
47
Category
Article
ISSN
0312-5963

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Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab