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Interaction of α-helical peptides with phospholipid membrane: effects of chain length and hydrophobicity of peptides

✍ Scribed by OHMORI, NAOYA ;NIIDOME, TAKURO ;HATAKEYAMA, TOMOMITSU ;MIHARA, HISAKAZU ;AOYAGI, HARUHIKO

Book ID
110893653
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
610 KB
Volume
51
Category
Article
ISSN
1397-002X

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It was previously found that a cationic amphiphilic peptide, Ac-(Leu-Ala-Arg-Leu) 3 -NHCH 3 (4 3 ), caused the destabilization of a phospholipid membrane and showed strong antibacterial activity [Lee et al. Biochim. Biophys. Acta 1986; 862: 211 -219]. In order to investigate the effect of changing h