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Interaction of Vinca Alkaloids with Tubulin: A Comparison of Vinblastine, Vincristine, and Vinorelbine †

✍ Scribed by Lobert, Sharon; Vulevic, Bojana; Correia, John J.


Book ID
120413510
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
319 KB
Volume
35
Category
Article
ISSN
0006-2960

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Energetics of vinca alkaloid interaction
✍ Lobert, Sharon ;Frankfurter, Anthony ;Correia, John J. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB 👁 2 views

A number of vinca alkaloids, including vincristine, vinblastine, and vinorelbine, are currently used in cancer chemotherapy. These three vinca alkaloids interact differently with a range of solid and hematologic tumors. To test the possibility that the tubulin isotype composition is an important det