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Interaction of urinary-type plasminogen activator with extracellular matrix proteins: Specific binding to vitronectin

✍ Scribed by Tammy L. Moser; Jan J. Enghild; Salvatore V. Pizzo; M. Sharon Stack


Book ID
119154419
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
140 KB
Volume
8
Category
Article
ISSN
0268-9499

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Plasminogen activator inhibitor type-1 (PAI-1) is bound to vitronectin (VN) in plasma and in the extracellular matrix. We previously employed a domainswapping approach to show that the high-affinity binding site for PAI-1 in VN is contained within residues 12-30 in the amino-terminal somatomedin B (