Interaction of triazolam and ketoconazole
โ Scribed by DavidJ. Greenblatt; LisaL. von Moltke; JeroldS. Harmatz; LisaM. Harrel; Sara Tobias; RichardI. Shader; C.Eugene Wright
- Book ID
- 118557237
- Publisher
- The Lancet
- Year
- 1995
- Tongue
- English
- Weight
- 139 KB
- Volume
- 345
- Category
- Article
- ISSN
- 0140-6736
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๐ SIMILAR VOLUMES
The influence of cimetidine on the pharmacokinetics of alprazolam and triazolam, two triazolobenzodiazepines metabolized by hepatic microsomal oxidation, was evaluated in a series of healthy volunteers. Subjects ingested single 1.0 mg dose of alprazolam or 0.5 mg doses of triazolam on two occasions,
Four normal volunteers each received three intraduodenal infusions of 0.5 mg triazolam solutions. Three treatments were: 1. a pH 2.3 solution in which 47 per cent of the dose had hydrolysed to form a triazolo-benzophenone (TB); 2. a pH 6.0 solution containing negligible TB; 3. the p H 6.0 solution