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Interaction of Topotecan, DNA Topoisomerase I Inhibitor, with Double-Stranded Polydeoxyribonucleotides. 1. Topotecan Dimerization in Solution

✍ Scribed by S. A. Strel'tsov; S. L. Grokhovskii; I. A. Kudelina; V. A. Oleinikov; A. L. Zhuze

Book ID: 110291285
Publisher: SP MAIK Nauka/Interperiodica
Year: 2001
Tongue: English
Weight: 143 KB
Volume: 35
Category: Article
ISSN: 0026-8933
DOI: 10.1023/a:1010422711817

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## Abstract Topotecan (TPT), a water‐soluble derivative of camptothecin, is a potent antitumor poison of human DNA topoisomerase I (top1) that stabilizes the cleavage complex between the enzyme and DNA. The role of the recently discovered TPT affinity to DNA remains to be defined. The aim of this w