Interaction of thiamine and its phosphate esters with Pt(II) and Pd(II)

✍ Scribed by N. Hadjiliadis; J. Markopoulos; O. Pneumatikakis; D. Katakis; T. Theophanides

• Publisher: Elsevier Science
• Year: 1977
• Tongue: English
• Weight: 737 KB
• Volume: 25
• Category: Article
• ISSN: 0020-1693
• DOI: 10.1016/s0020-1693(00)95686-x

✦ Synopsis

The reactions of ThiamineaHCl (ThH), Thiamine monophosphate*HCl (TMP) and Thiamine pyrophosphate (TPP) have been studied in aqueous solutions (pH -34) at room temperature. Two types of complexes have been characterized by elemental analyses, conductivity measurements, ir, 'H nmr and 13C nmr spectra: ionic 1:2 salts in which thiamine is present as a cation, and 1:l complexes in which the organic l&and is directly coordinated to the metal ions. The formulae of the ionic salts that were prepared are [MX,] *-[Th] '? and MThX3. The salts can easily be converted into 1:l products by stirring in water at room temperature, while the TPP analogs require excess of l&and. The I:1 complexes appear to have a zwitterionic structure and the metal is bound through NI of the pyrimidine ring of thiamine. These solid and stable complexes of thiamine are the first examples reported having a direct metal-to-nitrogen bond.