Interaction of the recombination pathways of bacteriophage λ and host Escherichia coli: Effects on λ recombination

✍ Scribed by Richard C. Unger; Harrison Echols; Alvin J. Clark

• Book ID: 118917328
• Publisher: Elsevier Science
• Year: 1972
• Tongue: English
• Weight: 536 KB
• Volume: 70
• Category: Article
• ISSN: 0022-2836
• DOI: 10.1016/0022-2836(72)90557-8

✦ Synopsis

The host He&C recombination pathway is inefficient for point mutants of phage X dofcrtivc in the viral general recombination pathway. This low level of X recombination can bc increased substantially by the presence of an additional point mut.ation in the gam gene of h or by the presence of a pathway of bacterial rccomhinntion alternative to the RAcBC pathway. Wo suggest that tho gam gene of A codas for a protein (y-protein) which provides for a specific inhibition of the RecBC recombination pathway.