Interaction of the nitric oxide signaling system with the Sphingomyelin cycle and Peroxidation on transmission of toxic signal of tumor necrosis factor-α in ischemia-reperfusion

Selenoorganic compound, ebselen, inhibit

Selenoorganic compound, ebselen, inhibits nitric oxide and tumor necrosis factor-α production by the modulation of Jun-N-terminal kinase and the NF-κb signaling pathway in rat Kupffer cells

✍ Naoya Shimohashi; Makoto Nakamuta; Koutaro Uchimura; Rie Sugimoto; Hiroaki Iwamo 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 267 KB 👁 1 views

In response to the bacterial endotoxin, LPS, Kupffer cells are induced to express NO and TNF-␣. These compounds are involved in hepatic inflammation/injury, especially that associated with endotoxic shock. In this study, we demonstrate that ebselen (2-phenyl-1,2-benzisoselenazol-3[2H]one), a selenoo