Interaction of the blood with natural and artificial surfaces edited by Edwin W. Salzman, Marcel-Dekker, 1981
✍ Scribed by Horbett, T. A.
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 141 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0021-9304
No coin nor oath required. For personal study only.
✦ Synopsis
Blood interactions with natural and artificial surfaces can result in a wide variety of clinical problems. The prevalence of cardiovascular disease and the limitations of present approaches to these diseases has led to the need to better understand the nature of blood-material interactions. This book is the result of a symposium on this topic organized by E. W. Salzman and held in August, 1980 at the annual meeting of the International Committee on Thrombosis and Hemostasis.
The book consists of ten chapters by scientists with a wide variety of formal training and research involvement with blood. The text and figures are easy to read and in general the book is nicely finished. Some lapses in editing are evident (e.g. the listing of fibrinogen concentration in "serum" in Chapter 1 and the prevalence of jargon) but generally the number of errors are few. Five chapters concern blood proteins, four focus on blood cells and one provides an overview of the status of thromboresistant materials. The book is thus well rounded in content. The lack of any representation by two of the major groups studying blood-polymers interactions is a serious omission, however, which I found difficult to understand. As a result, readers not familiar with this field are recommended to consult older but more comprehensive works in addition to this one.
The chapter by Cooper and coworkers on "The Physics and Chemistry of Protein-Surface Interactions" consists of a useful description of some of the relevant properties of polymers (e.g. the glass transition temperatures), a brief description of some of the variables affecting protein adsorption, and a short presentation of adsorption results obtained in this groups studies with dogs. The description of polymers is laced with enough jargon to make the text rather unclear at times. The "adsorption" data is not clearly presented in that entrapment of bulk protein by the ongoing clotting reactions undoubtedly contributes to the amount of protein on the surfaces. Brash's chapter on "Protein Interactions with Surfaces" is a good review, well and clearly written, covering some of the same ground as the preceding chapter. However, the inclusion of some important ideas and thoughtful comments were quite stimulating and clearly reflect the long commitment to this problem by Brash.
Mosher's chapter on the "Influence of Proteins on Platelet-Surface Interactions" centers on the concept of adhesive proteins which can facilitate cell interactions with surfaces. Proteins from the plasma or platelet alpha granules may mediate this cell's responses. The review of work in this area is very good, clearly written, brief but highly relevant to the topic of the symposium.
Griffin's chapter on "Surface Dependent Activation of Blood Coagulation" reviews current ideas on the "intrinsic" coagulation pathway focusing on the early events in contact activation involving Factors XU, XI, prekallikrein and high molecular weight kininogen. Current hypotheses in this area are presented. The limitations of available