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Interaction of Tacrolimus (FK506) and Its Metabolites with FKBP and Calcineurin

✍ Scribed by K. Tamura; T. Fujimura; K. Iwasaki; S. Sakuma; T. Fujitsu; K. Nakamura; K. Shimomura; T. Kuno; C. Tanaka; M. Kobayashi

Book ID
115574978
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
311 KB
Volume
202
Category
Article
ISSN
0006-291X

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## Abstract FKBP51 is a member of the immunophilin family having intrinsic peptidyl‐prolyl cis‐trans‐isomerase (PPIase) activity. Its enzymatic activity is inhibited by binding either immunosuppressive agent FK506 or rapamycin. Similar to FKBP12, but at higher concentrations of FK506, FKBP51 has be