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Interaction of St. John's Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding

โœ Scribed by Patricia A. Murphy; Steven E. Kern; Frank Z. Stanczyk; Carolyn L. Westhoff


Book ID
116381054
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
161 KB
Volume
71
Category
Article
ISSN
0010-7824

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## Abstract Concomitant administration of botanical supplements with drugs that are Pโ€glycoprotein (Pโ€gp) substrates may produce clinically significant herbโ€drug interactions. This study evaluated the effects of St. John's wort and __Echinacea__ on the pharmacokinetics of digoxin, a recognized Pโ€gp