Interaction of silicate dust with erythrocyte ghost membrane: In vitro studies

✍ Scribed by Shivendra Vikram Singh; Ballabh Das; M. Firoze Khan; Qamar Rahman

• Book ID: 102291718
• Publisher: John Wiley and Sons
• Year: 1984
• Tongue: English
• Weight: 446 KB
• Volume: 4
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550040504

✦ Synopsis

Composition of the erythrocyte ghost membrane obtained from slate-dust-lysed and hypotonically lysed erythrocytes were compared in vitro. The protein and cholesterol contents were unaltered, whilst phospholipid and glycosamine contents decreased significantly in the slate-dust-lysed preparation of erythrocyte ghost membrane. Na+, K+-ATPase activity remained unchanged, whilst acetylcholinesterase activity was decreased slightly by slate dust treatment. Further, binding of silicic acid, dissolving out of slate dust, was observed with a component of erythrocyte ghost membrane protein having molecular weight around 90 000 daltons. The significance of the findings is discussed.