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Interaction of Ru(II) Complex with Yeast tRNA Studied by Isothermal Titration Calorimetry

✍ Scribed by Xu Hong; Liu Jian-Hong; Liu Zhi-Gang; Liang Yi; Zhang Peng; Du Fen; Zhou Bing-Rui; Ji Liang-Nian

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 50 KB
Volume: 23
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.200590659

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The interaction of metal complex with RNA has been studied by isothermal titration calorimetry (ITC) for the first time. ITC experiments show that complex [Ru(phen)2MPIP]^2+^ {phen=1,10‐phenanthroline, MPIP=2‐(4‐methylphenyl)imidazo[4,5‐f]‐1,10‐phenanthroline} interacts with yeast tRNA in terms of a model for a single set of identical sites through intercalation, which is consistent with our previous observation obtained from spectroscopic methods, and this binding process was driven by a moderately favorable enthalpy decrease in combination with a moderately favorable entropy increase, suggesting that ITC is an effective method for deep studying the interactions of metal complexes with RNA.

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