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Interaction of poly(α-L-glutamic acid) and sodium poly(α-L-glutamate) with solvent components in water–2-chloroethanol mixtures

✍ Scribed by M. Morcellet; C. Loucheux

Publisher
Wiley (John Wiley & Sons)
Year
1980
Tongue
English
Weight
698 KB
Volume
19
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The preferential interaction of sodium poly(α‐L‐glutamate) and poly(α‐L‐glutamic acid) with the solvent components in water/2‐chloroethanol mixtures has been determined using density‐increment measurements. The degree of preferential interaction was deduced from the density increments at constant molality of 2‐chloroethanol and at constant chemical potential of 2‐chloroethanol. Sodium poly(α‐L‐glutamate) and poly(α‐L‐glutamic acid) are both preferentially hydrated in the whole range of solvent composition. A dehydration process occurs during the 2‐chloroethanol‐induced coil‐to‐helix transition of sodium poly(α‐L‐glutamate). This dehydration process was attributed to the release of some moles of water from the neighborhood of the peptide bond during the nucleation of the helix. After the conformational transition, sodium poly(α‐L‐glutamate) is solvated by one 2‐chloroethanol molecule. The location of water and 2‐chloroethanol molecules in the different parts of the residue (more polar and less polar portions) is also discussed.

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