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Interaction of polynucleotides with cultured mammalian cells: III. Initial binding at cell surfaces

✍ Scribed by E. Mayhew

Book ID
118876548
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
576 KB
Volume
86
Category
Article
ISSN
0014-4827

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## Abstract It was known that polycationic polymers enhance the entry of macromolecules into cells. We now show that polynucleotides may have similar effects, when used as large aggregates. Poly(1‐vinylcytosine):polyinosinic acid, an inducer of interferon production in human cells, can cause at 40