The optimal dose and schedule of paclitaxel in combination with irradiation have not been determined yet. The aim of this study was to compare the in vitro cytotoxicity and enhancement of radiation sensitization as a function of single vs. fractionated paclitaxel exposure. A fibroblast cell line (B1
Interaction of paclitaxel (Taxol®) and irradiation
✍ Scribed by Nils Cordes; Ludwig Plasswilm; Rolf Sauer
- Book ID
- 110658897
- Publisher
- Springer
- Year
- 1999
- Tongue
- German
- Weight
- 704 KB
- Volume
- 175
- Category
- Article
- ISSN
- 0179-7158
No coin nor oath required. For personal study only.
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Taxol™ (paclitaxel) , a promising agent for use in ovarian and breast cancer, was incorporated into lipid vesicles (liposomes) composed of different saturated and unsaturated phosphatidylcholines, as well as saturated phosphatidylcholines mixed with the anionic phospholipid 1,2-dimyristoyl-sn-glyce
## Abstract Reductive cleavage of the C13 side chain of Taxol® (1, paclitaxel) followed by regioselective silylation gave 7‐triethylsilylbaccatin III (4). 3‐O‐Triethylsilylation of 5 and subsequent reaction with benzoyl chloride‐__C__7‐^14^__C__ gave azetidinone 7. Coupling of 4 and 7 followed by d