Interaction of p-benzoquinone and mitomycin C with complementary base pairs

✍ Scribed by H. Chojnacki; A. Sawaryn

• Book ID: 104580915
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 393 KB
• Volume: 23
• Category: Article
• ISSN: 0020-7608
• DOI: 10.1002/qua.560230242

✦ Synopsis

Abstract

Quantum chemical studies on interaction of p‐benzoquinone and mitomycin C with complementary base pairs have been performed. The empirical potential function and semitheoretical algorithm were applied for estimation of intermolecular interaction energy. Non‐negligible intercalation of the quinone ring into fragments of nucleic acid seems to be justified. Extensive calculations on the specificity of mitomycin C intercalation were performed using AGNAS/IMNAS algorithm based on an empirical potential function. No clear preference for intercalation into any kind of base pairs was found.