Interaction of norethindrone and isoniazid following their oral co-administration to the minipig

✍ Scribed by J. C. K. Loo; N. Jordan; J. A. Menzies; H. Watanabe

• Book ID: 101701371
• Publisher: John Wiley and Sons
• Year: 1983
• Tongue: English
• Weight: 223 KB
• Volume: 4
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510040206

✦ Synopsis

Abstract

Following the oral co‐administration of isonicotinic acid hydrazide and norethindrone to minipigs, the hydrazone of norethindrone was detected in plasma as its p‐methoxybenzaldehyde derivative, using a high performance liquid chromatographic technique. The suspected precursor of the hydrazone of norethindrone was isonicotinyl hydrazone of norethindrone, a reaction product probably formed between norethindrone and isonicotinic acid hydrazide in the acid environment of the stomach. An in vitro liver metabolite of isonicotinyl hydrazone of norethindrone was isolated following derivatization with p‐methoxybenzaldehyde and characterized by high resolution mass spectrometric and radiochemical techniques. The results demonstrated that the hydrazone of norethindrone is a metabolite of isonicotinyl hydrazone of norethindrone.