๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Interaction of naproxen with cholestyramine

โœ Scribed by M. V. Calvo; A. Dominguez-Gil

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
411 KB
Volume
5
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

โœฆ Synopsis

In vitro ' and 'in vivo' studies were used to determine the interaction of naproxen, an antiinflammatory agent, and cholestyramine, a hypocholesterolemic substance.

Cholestyramine shows a marked affinity for naproxen and the intensity of this is governed by the pH values. The maximum amount of naproxen adsorbed by the resin is close to 2.2 mM g-I .

The pharmacokinetics of naproxen was studied in eight healthy volunteers after concurrent oral administration in a single dose of 250mg of naproxen and 4g of cholestyramine. The resin causes an important delay in the incorporation of naproxen into the systemic circulation, though no significant modifications are seen to take place in any other pharmacokinetic parameters of the drug.

๐Ÿ“œ SIMILAR VOLUMES

Absence of pharmacokinetic interaction b
Absence of pharmacokinetic interaction between orally co-administered naproxen sodium and diphenhydramine hydrochloride
โœ R.D. Toothaker; S.H. Barker; M.V. Gillen; S.A. Helsinger; C.G. Kindberg; T.L. Hu ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 116 KB ๐Ÿ‘ 1 views

The potential for a pharmacokinetic interaction between naproxen and diphenhydramine was examined in a randomized three-way crossover design with a 1-week washout between dosing. Single oral doses of 220 mg of naproxen sodium and 50 mg of diphenhydramine hydrochloride were given separately and toget