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Interaction of methotrexate with lipotropic factors in rat liver

✍ Scribed by Dean J. Tuma; Anthony J. Barak; Michael F. Sorrell

Book ID
115772710
Publisher
Elsevier Science
Year
1975
Tongue
English
Weight
362 KB
Volume
24
Category
Article
ISSN
0006-2952

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## Abstract Because of the frequent reports of hepatic toxicity associated with long‐term administration of methotrexate, a rat model was developed utilizing daily methotrexate administration. This model revealed an incidence of fatty metamorphosis of over 80 percent, atrophy and necrosis of 30 per