✦ LIBER ✦

Interaction of human liver connective tissue cells, skin fibroblasts and smooth muscle cells with collagen gels

✍ Scribed by Alvaro N. A. Monteiro; Dr. Radovan Borojevic

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 830 KB
Volume: 7
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840070409

No coin nor oath required. For personal study only.

✦ Synopsis

Interactions of liver connective tissue cells, skin fibroblasts and smooth muscle cells with collagen gels in uitro were studied and compared.

Liver connective tissue cells showed the lowest rate of migration into the gel and the highest speed of gel contraction, reflecting their high adhesiveness to the substrate as compared to the other cell lines studied.

The analysis of their ultrastructural morphology showed that liver connective tissue cells and smooth muscle cells developed cytoskeletal and cytoplasmic organelle polarities, in response to the contact with gel surface. This polarity was lost when cells were embedded in the gel. Skin fibroblasts did not show this characteristic, neither on top nor in the gel.

Although liver connective tissue cells have been recognized as analogous to smooth muscle cells, they represent a defined cell population, present in fibrotic livers, with specific behavior and with particular relationship to the extracellular matrix.

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